4KS6

Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 166-174 stretch

4KS6 の概要

• エントリーDOI: 10.2210/pdb4ks6/pdb
• 関連するPDBエントリー: 4EJ5 4EL4 4ELC 4KTX
• 関連するBIRD辞書のPRD_ID: PRD_001078
• 分子名称: Botulinum neurotoxin A light chain, Peptide inhibitor MPT-DPP-DAR-G-DPN-NH2, ZINC ION, ... (9 entities in total)
• 機能のキーワード: clostridial neurotoxin zinc protease, peptidase_m27, snap 25, covalent inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Clostridium botulinum A; 詳細
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52323.25

構造登録者

Stura, E.A.,Vera, L.,Guitot, K.,Dive, V. (登録日: 2013-05-17, 公開日: 2014-06-25, 最終更新日: 2023-09-20)

• 主引用文献: Guitot, K.,Vera, L.,Le Roux, L.,Bregant, S.,Ptchelkine, D.,Beau, F.,Stura, E.A.,Dive, V.; Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A; To be Published,

実験手法

X-RAY DIFFRACTION (1.93 Å)