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4EJ5

Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A wild-type

Summary for 4EJ5
Entry DOI10.2210/pdb4ej5/pdb
Related2ISE 3BWI 4EL4 4ELC
DescriptorBotulinum neurotoxin A light chain, ZINC ION, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywordsmetalloprotease, peptidase m27 superfamily, clostridial neurotoxin zinc protease, human target snap-25, hydrolase
Biological sourceClostridium botulinum
Cellular locationBotulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
Total number of polymer chains1
Total formula weight51474.24
Authors
Stura, E.A.,Vera, L.,Dive, V. (deposition date: 2012-04-06, release date: 2012-08-15, Last modification date: 2023-09-20)
Primary citationStura, E.A.,Le Roux, L.,Guitot, K.,Garcia, S.,Bregant, S.,Beau, F.,Vera, L.,Collet, G.,Ptchelkine, D.,Bakirci, H.,Dive, V.
Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165.
J.Biol.Chem., 287:33607-33614, 2012
Cited by
PubMed: 22869371
DOI: 10.1074/jbc.M112.396697
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.87 Å)
Structure validation

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