4EJ5
Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A wild-type
Summary for 4EJ5
Entry DOI | 10.2210/pdb4ej5/pdb |
Related | 2ISE 3BWI 4EL4 4ELC |
Descriptor | Botulinum neurotoxin A light chain, ZINC ION, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | metalloprotease, peptidase m27 superfamily, clostridial neurotoxin zinc protease, human target snap-25, hydrolase |
Biological source | Clostridium botulinum |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845 |
Total number of polymer chains | 1 |
Total formula weight | 51474.24 |
Authors | Stura, E.A.,Vera, L.,Dive, V. (deposition date: 2012-04-06, release date: 2012-08-15, Last modification date: 2023-09-20) |
Primary citation | Stura, E.A.,Le Roux, L.,Guitot, K.,Garcia, S.,Bregant, S.,Beau, F.,Vera, L.,Collet, G.,Ptchelkine, D.,Bakirci, H.,Dive, V. Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165. J.Biol.Chem., 287:33607-33614, 2012 Cited by PubMed: 22869371DOI: 10.1074/jbc.M112.396697 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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