4KQU
Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
Summary for 4KQU
Entry DOI | 10.2210/pdb4kqu/pdb |
Related | 4KFA 4KPD 4KPJ 4KQ5 4KQS |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, dimethylallyl pyrophosphate, isoprenoid pathway, cholesterol synthesis, bisphosphonates |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43616.96 |
Authors | Barnett, B.L.,Tsoumpra, M.K.,Muniz, J.R.C.,Walter, R.L. (deposition date: 2013-05-15, release date: 2014-04-30, Last modification date: 2023-09-20) |
Primary citation | Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.,Kavanagh, K.L.,Evdokimov, A.G.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate To be Published, |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
Download full validation report