4KNW
The crystal structure of human HDHD4 IN COMPLEX WITH MAGNESIUM AND THE PHOSPHATE MIMETIC VANADATE
Summary for 4KNW
Entry DOI | 10.2210/pdb4knw/pdb |
Related | 4KNV |
Descriptor | N-acylneuraminate-9-phosphatase, VANADATE ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | n-acetylneuraminate, neu5ac-9-phosphate, carbohydrate metabolism, n-acetylneuraminic acid phosphatase, nanp, hdhd4, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 86791.34 |
Authors | Klei, H.E. (deposition date: 2013-05-10, release date: 2013-06-26, Last modification date: 2023-09-20) |
Primary citation | Kim, S.H.,Constantine, K.L.,Duke, G.J.,Goldfarb, V.,Hunt, J.T.,Johnson, S.,Kish, K.,Klei, H.E.,McDonnell, P.A.,Metzler, W.J.,Mueller, L.,Poss, M.A.,Fairchild, C.R.,Bhide, R.S. Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex. Bioorg.Med.Chem.Lett., 23:4107-4111, 2013 Cited by PubMed: 23747226DOI: 10.1016/j.bmcl.2013.05.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.699 Å) |
Structure validation
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