4KNW

The crystal structure of human HDHD4 IN COMPLEX WITH MAGNESIUM AND THE PHOSPHATE MIMETIC VANADATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006045	biological_process	N-acetylglucosamine biosynthetic process
A	0006054	biological_process	N-acetylneuraminate metabolic process
A	0006055	biological_process	CMP-N-acetylneuraminate biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0046380	biological_process	N-acetylneuraminate biosynthetic process
A	0050124	molecular_function	N-acylneuraminate-9-phosphatase activity
A	1901137	biological_process	carbohydrate derivative biosynthetic process
B	0005829	cellular_component	cytosol
B	0006045	biological_process	N-acetylglucosamine biosynthetic process
B	0006054	biological_process	N-acetylneuraminate metabolic process
B	0006055	biological_process	CMP-N-acetylneuraminate biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0046380	biological_process	N-acetylneuraminate biosynthetic process
B	0050124	molecular_function	N-acylneuraminate-9-phosphatase activity
B	1901137	biological_process	carbohydrate derivative biosynthetic process
C	0005829	cellular_component	cytosol
C	0006045	biological_process	N-acetylglucosamine biosynthetic process
C	0006054	biological_process	N-acetylneuraminate metabolic process
C	0006055	biological_process	CMP-N-acetylneuraminate biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0046380	biological_process	N-acetylneuraminate biosynthetic process
C	0050124	molecular_function	N-acylneuraminate-9-phosphatase activity
C	1901137	biological_process	carbohydrate derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE VO4 A 301

Chain	Residue
A	ASP14
A	LEU15
A	ASP16
A	THR133
A	ASN134
A	LYS166
A	MG302

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	ASP191
A	VO4301
A	ASP14
A	ASP16

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE VO4 B 301

Chain	Residue
B	ASP14
B	LEU15
B	ASP16
B	THR133
B	ASN134
B	LYS166
B	ASP196
B	MG302

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 302

Chain	Residue
B	ASP14
B	ASP16
B	ASP191
B	THR192
B	VO4301

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE VO4 C 301

Chain	Residue
C	ASP14
C	LEU15
C	ASP16
C	THR133
C	ASN134
C	LYS166
C	ASP196
C	MG302

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 302

Chain	Residue
C	ASP14
C	ASP16
C	ASP191
C	VO4301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KNW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"PDB data bank","title":"The crystal structure of human N-acetylneuraminic acid phosphatase, NANP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2W4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---