4KNW

The crystal structure of human HDHD4 IN COMPLEX WITH MAGNESIUM AND THE PHOSPHATE MIMETIC VANADATE

Summary for 4KNW

Related4KNV
DescriptorN-acylneuraminate-9-phosphatase, VANADATE ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsn-acetylneuraminate, neu5ac-9-phosphate, carbohydrate metabolism, n-acetylneuraminic acid phosphatase, nanp, hdhd4, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains3
Total molecular weight86791.34
Authors
Klei, H.E. (deposition date: 2013-05-10, release date: 2013-06-26, Last modification date: 2013-07-10)
Primary citation
Kim, S.H.,Constantine, K.L.,Duke, G.J.,Goldfarb, V.,Hunt, J.T.,Johnson, S.,Kish, K.,Klei, H.E.,McDonnell, P.A.,Metzler, W.J.,Mueller, L.,Poss, M.A.,Fairchild, C.R.,Bhide, R.S.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg.Med.Chem.Lett., 23:4107-4111, 2013
PubMed: 23747226 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2013.05.052
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.699 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29641.7%2.0%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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