4KNR
Hin GlmU bound to WG188
Summary for 4KNR
Entry DOI | 10.2210/pdb4knr/pdb |
Related | 4KNX 4KPX 4KPZ 4KQL |
Descriptor | Bifunctional protein GlmU, N-{4-[(2-benzyl-7-hydroxy-6-methoxyquinazolin-4-yl)amino]phenyl}benzamide, TETRAETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | beta helix, cell wall biosynthesis, inhibitor bound, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Haemophilus influenzae |
Cellular location | Cytoplasm : P43889 |
Total number of polymer chains | 1 |
Total formula weight | 50739.96 |
Authors | Doig, P.,Kazmirski, S.L.,Boriack-Sjodin, P.A. (deposition date: 2013-05-10, release date: 2014-10-15, Last modification date: 2024-02-28) |
Primary citation | Doig, P.,Boriack-Sjodin, P.A.,Dumas, J.,Hu, J.,Itoh, K.,Johnson, K.,Kazmirski, S.,Kinoshita, T.,Kuroda, S.,Sato, T.O.,Sugimoto, K.,Tohyama, K.,Aoi, H.,Wakamatsu, K.,Wang, H. Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg.Med.Chem., 22:6256-6269, 2014 Cited by PubMed: 25262942DOI: 10.1016/j.bmc.2014.08.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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