4KNG

Crystal structure of human LGR5-RSPO1-RNF43

Summary for 4KNG

• Entry DOI: 10.2210/pdb4kng/pdb
• Descriptor: Leucine-rich repeat-containing G-protein coupled receptor 5, R-spondin-1, E3 ubiquitin-protein ligase RNF43, ... (6 entities in total)
• Functional Keywords: leucine-rich repeat, cysteine-rich domain, furin-repeat, protease-associated domain, ligand recognition, protein-protein interaction, n-linked glycosylation, membrane protein, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 178882.88

Authors

Chen, P.H.,He, X. (deposition date: 2013-05-09, release date: 2013-06-19, Last modification date: 2020-07-29)

• Primary citation: Chen, P.H.,Chen, X.,Lin, Z.,Fang, D.,He, X.; The structural basis of R-spondin recognition by LGR5 and RNF43.; Genes Dev., 27:1345-1350, 2013; PubMed: 23756651; DOI: 10.1101/gad.219915.113

Experimental method

X-RAY DIFFRACTION (2.5 Å)