4KNG
Crystal structure of human LGR5-RSPO1-RNF43
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Leucine-rich repeat-containing G-protein coupled receptor 5 | polymer | 531 | 59278.4 | 2 | UniProt (O75473) Pfam (PF01462) Pfam (PF13855) Pfam (PF12799) In PDB | Homo sapiens (human) | G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38 |
2 | M, P | R-spondin-1 | polymer | 115 | 12362.3 | 2 | UniProt (Q2MKA7) Pfam (PF15913) In PDB | Homo sapiens (human) | Roof plate-specific spondin-1, hRspo1 |
3 | E, F | E3 ubiquitin-protein ligase RNF43 | polymer | 160 | 17550.2 | 2 | UniProt (Q68DV7) Pfam (PF18212) In PDB | Homo sapiens (human) | RING finger protein 43 |
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | B | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
6 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 557 (UniProt: O75473)
M, P: 35 - 144 (UniProt: Q2MKA7)
E, F: 44 - 198 (UniProt: Q68DV7)
PDB | External Database | Details |
---|---|---|
Gly 30 | - | expression tag |
Pro 31 | - | expression tag |
Ala 558 | - | expression tag |
Ala 559 | - | expression tag |
Ala 560 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 33 | - | expression tag |
Pro 34 | - | expression tag |
Ala 145 | - | expression tag |
Ala 146 | - | expression tag |
Ala 147 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 42 | - | expression tag |
Pro 43 | - | expression tag |
Ala 199 | - | expression tag |
Ala 200 | - | expression tag |
Ala 201 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 178381.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 501.1 | |
All* | Total formula weight | 178882.9 |