4KLZ

Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis

Summary for 4KLZ

• Entry DOI: 10.2210/pdb4klz/pdb
• Related: 5P21
• Descriptor: GTP-binding protein Rit1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: small gtpase, molecular switch (gtpase), gdp/gtp binding, protein binding, guanine nucleotide binding
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: Q92963
• Total number of polymer chains: 1
• Total formula weight: 20553.29

Authors

Shah, D.M.,Kobayashi, M.,Keizers, P.H.,Tuin, A.W.,Ab, E.,Manning, L.,Rzepiela, A.A.,Andrews, M.,Hoedemaeker, F.J.,Siegal, G. (deposition date: 2013-05-07, release date: 2014-09-17, Last modification date: 2023-09-20)

• Primary citation: Shah, D.M.,Kobayashi, M.,Keizers, P.H.,Tuin, A.W.,Ab, E.,Manning, L.,Rzepiela, A.A.,Andrews, M.,Hoedemaeker, F.J.,Siegal, G.; Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)