4KKX

Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site

4KKX の概要

• エントリーDOI: 10.2210/pdb4kkx/pdb
• 関連するPDBエントリー: 2CLE 2CLF 2CLM 3CEP 3PR2 4HPJ
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (9 entities in total)
• 機能のキーワード: lyase, carbon-oxygen lyase, tryptophan biosynthesis, f6f, allosteric enzyme, 2-aminophenol quinonoid, biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73576.42

構造登録者

Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (登録日: 2013-05-06, 公開日: 2014-01-01, 最終更新日: 2023-09-20)

• 主引用文献: Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F.; Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.; Biochemistry, 52:6396-6411, 2013; PubMed: 23952479; DOI: 10.1021/bi400795e

実験手法

X-RAY DIFFRACTION (1.77 Å)