3PR2

Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site

Summary for 3PR2

Entry DOI	10.2210/pdb3pr2/pdb
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
Functional Keywords	alpha-beta barrel, tim-barrel, tryptophan synthesis, lyase
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Total number of polymer chains	2
Total formula weight	71926.89
Authors	Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.M.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.A.,Schlichting, I.,Dunn, M.F.,Mueller, L.J. (deposition date: 2010-11-29, release date: 2011-02-09, Last modification date: 2024-02-21)
Primary citation	Lai, J.,Niks, D.,Wang, Y.,Domratcheva, T.,Barends, T.R.,Schwarz, F.,Olsen, R.A.,Elliott, D.W.,Fatmi, M.Q.,Chang, C.E.,Schlichting, I.,Dunn, M.F.,Mueller, L.J. X-ray and NMR Crystallography in an Enzyme Active Site: The Indoline Quinonoid Intermediate in Tryptophan Synthase. J.Am.Chem.Soc., 133:4-7, 2011 Cited by PubMed: 21142052 DOI: 10.1021/ja106555c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation