4KG8

Crystal structure of light mutant

Summary for 4KG8

• Entry DOI: 10.2210/pdb4kg8/pdb
• Related: 3K51 3MHD 3MI8 4EN0 4FHQ 4J6G
• Descriptor: Tumor necrosis factor ligand superfamily member 14 (2 entities in total)
• Functional Keywords: structural genomics, psi-biology, new york structural genomics research consortium, nysgrc, immunity, tnf superfamily, hvem, dcr3, n-glycosylation, membrane, secreted protein, cytokine, atoms-to-animals: the immune function network, jelly-roll fold, bind tnf receptor hvem and ltbr, ltbr, protein structure initiative, ifn
• Biological source: Homo sapiens (human)
• Cellular location: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. Isoform 2: Cytoplasm: O43557
• Total number of polymer chains: 3
• Total formula weight: 51625.31

Authors

Liu, W.,Zhan, C.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC),Atoms-to-Animals: The Immune Function Network (IFN) (deposition date: 2013-04-28, release date: 2013-08-07, Last modification date: 2023-09-20)

• Primary citation: Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C.; Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.; Structure, 22:1252-1262, 2014; PubMed: 25087510; DOI: 10.1016/j.str.2014.06.013

Experimental method

X-RAY DIFFRACTION (2.25 Å)