Summary for 4KFB
| Entry DOI | 10.2210/pdb4kfb/pdb |
| Descriptor | REVERSE TRANSCRIPTASE/RIBONUCLEASE H, EXORIBONUCLEA P66 RT, P51 RT, ethyl pyrazolo[1,5-a]pyridine-3-carboxylate, ... (6 entities in total) |
| Functional Keywords | rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, hydrolase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) More |
| Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
| Total number of polymer chains | 2 |
| Total formula weight | 115423.72 |
| Authors | Bauman, J.D.,Patel, D.,Arnold, E. (deposition date: 2013-04-26, release date: 2013-05-15, Last modification date: 2024-02-28) |
| Primary citation | Bauman, J.D.,Patel, D.,Dharia, C.,Fromer, M.W.,Ahmed, S.,Frenkel, Y.,Vijayan, R.S.,Eck, J.T.,Ho, W.C.,Das, K.,Shatkin, A.J.,Arnold, E. Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening. J.Med.Chem., 56:2738-, 2013 Cited by PubMed: 23342998DOI: 10.1021/JM301271J PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.854 Å) |
Structure validation
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