4KFB

HIV-1 reverse transcriptase with bound fragment at NNRTI adjacent site

「4I7G」から置き換えられました

4KFB の概要

• エントリーDOI: 10.2210/pdb4kfb/pdb
• 分子名称: REVERSE TRANSCRIPTASE/RIBONUCLEASE H, EXORIBONUCLEA P66 RT, P51 RT, ethyl pyrazolo[1,5-a]pyridine-3-carboxylate, ... (6 entities in total)
• 機能のキーワード: rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, hydrolase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115423.72

構造登録者

Bauman, J.D.,Patel, D.,Arnold, E. (登録日: 2013-04-26, 公開日: 2013-05-15, 最終更新日: 2024-02-28)

• 主引用文献: Bauman, J.D.,Patel, D.,Dharia, C.,Fromer, M.W.,Ahmed, S.,Frenkel, Y.,Vijayan, R.S.,Eck, J.T.,Ho, W.C.,Das, K.,Shatkin, A.J.,Arnold, E.; Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening.; J.Med.Chem., 56:2738-, 2013; PubMed: 23342998; DOI: 10.1021/JM301271J

実験手法

X-RAY DIFFRACTION (1.854 Å)