4KEL
Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)
Summary for 4KEL
Entry DOI | 10.2210/pdb4kel/pdb |
Related | 2bdg 2bdh 2bdi 4K1E 4K8Y 4KGA |
Related PRD ID | PRD_001059 |
Descriptor | Kallikrein-4, Trypsin inhibitor 1 (3 entities in total) |
Functional Keywords | bowman-birk inhibitor, protease, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 25505.87 |
Authors | Ilyichova, O.V.,Swedberg, J.E.,de Veer, S.J.,Sit, K.C.,Harris, J.M.,Buckle, A.M. (deposition date: 2013-04-25, release date: 2014-04-30, Last modification date: 2023-11-08) |
Primary citation | Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M. KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58:2524-2533, 2019 Cited by PubMed: 31058493DOI: 10.1021/acs.biochem.9b00191 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.148 Å) |
Structure validation
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