4KEL

Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)

4KEL の概要

• エントリーDOI: 10.2210/pdb4kel/pdb
• 関連するPDBエントリー: 2bdg 2bdh 2bdi 4K1E 4K8Y 4KGA
• 関連するBIRD辞書のPRD_ID: PRD_001059
• 分子名称: Kallikrein-4, Trypsin inhibitor 1 (3 entities in total)
• 機能のキーワード: bowman-birk inhibitor, protease, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 25505.87

構造登録者

Ilyichova, O.V.,Swedberg, J.E.,de Veer, S.J.,Sit, K.C.,Harris, J.M.,Buckle, A.M. (登録日: 2013-04-25, 公開日: 2014-04-30, 最終更新日: 2023-11-08)

• 主引用文献: Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M.; KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.; Biochemistry, 58:2524-2533, 2019; PubMed: 31058493; DOI: 10.1021/acs.biochem.9b00191

実験手法

X-RAY DIFFRACTION (1.148 Å)