4KC1

Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate

Summary for 4KC1

Entry DOI	10.2210/pdb4kc1/pdb
Related	4KC2 4KC4
Descriptor	Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, MANGANESE (II) ION, octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside, ... (5 entities in total)
Functional Keywords	gta superfanily, blood group proteins, glycosyltransferase, fuc-gal, adp-gal, adp-galnac, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
Total number of polymer chains	1
Total formula weight	34768.94
Authors	Cuesta-Seijo, J.A.,Wang, S.,Lafont, D.,Vidal, S.,Palcic, M.M. (deposition date: 2013-04-24, release date: 2013-09-11, Last modification date: 2023-09-20)
Primary citation	Wang, S.,Cuesta-Seijo, J.A.,Lafont, D.,Palcic, M.M.,Vidal, S. Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate. Chemistry, 19:15346-15357, 2013 Cited by PubMed: 24108680 DOI: 10.1002/chem.201301871 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation