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4KBQ

Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains

Summary for 4KBQ
Entry DOI10.2210/pdb4kbq/pdb
Related2C2L 3LOF 3Q49 4KBO
DescriptorE3 ubiquitin-protein ligase CHIP, Heat shock cognate 71 kDa protein (3 entities in total)
Functional Keywordstpr, e3 ubiquitin ligase, hsc70, ligase-protein binding complex, ligase/protein binding
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm : Q9UNE7 P11142
Total number of polymer chains4
Total formula weight54615.60
Authors
Page, R.C.,Amick, J.,Nix, J.C.,Misra, S. (deposition date: 2013-04-23, release date: 2015-01-14, Last modification date: 2023-09-20)
Primary citationZhang, H.,Amick, J.,Chakravarti, R.,Santarriaga, S.,Schlanger, S.,McGlone, C.,Dare, M.,Nix, J.C.,Scaglione, K.M.,Stuehr, D.J.,Misra, S.,Page, R.C.
A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins.
Structure, 23:472-482, 2015
Cited by
PubMed: 25684577
DOI: 10.1016/j.str.2015.01.003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.91 Å)
Structure validation

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