4KBQ
Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains
Summary for 4KBQ
Entry DOI | 10.2210/pdb4kbq/pdb |
Related | 2C2L 3LOF 3Q49 4KBO |
Descriptor | E3 ubiquitin-protein ligase CHIP, Heat shock cognate 71 kDa protein (3 entities in total) |
Functional Keywords | tpr, e3 ubiquitin ligase, hsc70, ligase-protein binding complex, ligase/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : Q9UNE7 P11142 |
Total number of polymer chains | 4 |
Total formula weight | 54615.60 |
Authors | Page, R.C.,Amick, J.,Nix, J.C.,Misra, S. (deposition date: 2013-04-23, release date: 2015-01-14, Last modification date: 2023-09-20) |
Primary citation | Zhang, H.,Amick, J.,Chakravarti, R.,Santarriaga, S.,Schlanger, S.,McGlone, C.,Dare, M.,Nix, J.C.,Scaglione, K.M.,Stuehr, D.J.,Misra, S.,Page, R.C. A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins. Structure, 23:472-482, 2015 Cited by PubMed: 25684577DOI: 10.1016/j.str.2015.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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