4KBQ

Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	E3 ubiquitin-protein ligase CHIP	polymer	139	15884.1	2	UniProt (Q9UNE7) Pfam (PF12895) In PDB	Homo sapiens (human)	Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1
2	D, C	Heat shock cognate 71 kDa protein	polymer	101	11423.7	2	UniProt (P11142) In PDB	Homo sapiens (human)	Heat shock 70 kDa protein 8
3		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, B: 21 - 154 (UniProt: Q9UNE7)

PDB	External Database	Details
Gly 16	-	expression tag
Ala 17	-	expression tag
Met 18	-	expression tag
Gly 19	-	expression tag
Ser 20	-	expression tag

D, C: 541 - 646 (UniProt: P11142)

PDB	External Database	Details
Gly 533	-	expression tag
Ile 534	-	expression tag
Asp 535	-	expression tag
Pro 536	-	expression tag
Phe 537	-	expression tag
Thr 538	-	expression tag
Glu 539	-	expression tag
Phe 540	-	expression tag
-	Pro 626	deletion
-	Gly 627	deletion
-	Gly 628	deletion
-	Gly 629	deletion
-	Ala 630	deletion
-	Pro 631	deletion
-	Pro 632	deletion
-	Ser 633	deletion
-	Gly 634	deletion
-	Gly 635	deletion
-	Ala 636	deletion
-	Ser 637	deletion
-	Ser 638	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	54615.6
All*	Total formula weight	54615.6

*Water molecules are not included.