4KBA

CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine inhibitor

Summary for 4KBA

• Entry DOI: 10.2210/pdb4kba/pdb
• Related: 4KB8 4KBC 4KBH 4KBK
• Descriptor: Casein kinase I isoform delta, 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ser/thr kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P48730
• Total number of polymer chains: 4
• Total formula weight: 156310.87

Authors

Liu, S. (deposition date: 2013-04-23, release date: 2013-09-18, Last modification date: 2024-02-28)

• Primary citation: Mente, S.,Arnold, E.,Butler, T.,Chakrapani, S.,Chandrasekaran, R.,Cherry, K.,Dirico, K.,Doran, A.,Fisher, K.,Galatsis, P.,Green, M.,Hayward, M.,Humphrey, J.,Knafels, J.,Li, J.,Liu, S.,Marconi, M.,McDonald, S.,Ohren, J.,Paradis, V.,Sneed, B.,Walton, K.,Wager, T.; Ligand-protein interactions of selective casein kinase 1 delta inhibitors.; J.Med.Chem., 56:6819-6828, 2013; PubMed: 23919824; DOI: 10.1021/jm4006324

Experimental method

X-RAY DIFFRACTION (1.98 Å)