4KBA

CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1QM A 401

Chain	Residue
A	ILE15
A	LEU135
A	ILE148
A	SER17
A	ILE23
A	ALA36
A	LYS38
A	MET80
A	MET82
A	LEU85
A	GLY86

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	ARG178
A	GLN214
A	GLY215
A	HOH543

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 403

Chain	Residue
A	SER267
A	ARG270
A	ARG274
D	ASN275
D	ARG279

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1QM B 401

Chain	Residue
B	ILE15
B	SER17
B	ILE23
B	ALA36
B	LYS38
B	MET80
B	MET82
B	LEU85
B	GLY86
B	LEU135
B	ILE148

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
B	ARG178
B	GLN214
B	GLY215
B	LYS224

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 403

Chain	Residue
B	ARG127
B	LYS154
B	LYS171

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1QM C 401

Chain	Residue
C	ILE15
C	SER17
C	ILE23
C	ALA36
C	MET80
C	MET82
C	LEU85
C	GLY86
C	LEU135
C	ILE148

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 402

Chain	Residue
B	ASN275
B	ARG279
C	SER267
C	ARG270
C	ARG274

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 403

Chain	Residue
C	ARG178
C	GLN214
C	GLY215
C	LYS224
C	HOH545

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1QM D 401

Chain	Residue
D	ILE15
D	ILE23
D	ALA36
D	LYS38
D	MET80
D	MET82
D	GLU83
D	LEU84
D	LEU85
D	GLY86
D	LEU135
D	ILE148

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 402

Chain	Residue
D	ARG178
D	GLN214
D	GLY215
D	LYS224

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 403

Chain	Residue
D	ARG127
D	LYS154
D	LYS171

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 404

Chain	Residue
D	ARG192
D	LYS263

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK

Chain	Residue	Details
A	ILE15-LYS38

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM

Chain	Residue	Details
A	PHE124-MET136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP128
B	ASP128
C	ASP128
D	ASP128

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE15
A	LYS38
B	ILE15
B	LYS38
C	ILE15
C	LYS38
D	ILE15
D	LYS38

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