4KB8

CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANAMINE ligand

Summary for 4KB8

• Entry DOI: 10.2210/pdb4kb8/pdb
• Related: 4KBA 4KBC 4KBH 4KBK
• Descriptor: Casein kinase I isoform delta, 1-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}-N-methylmethanamine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: ser/thr kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P48730
• Total number of polymer chains: 4
• Total formula weight: 156034.70

Authors

Liu, S. (deposition date: 2013-04-23, release date: 2013-09-18, Last modification date: 2024-02-28)

• Primary citation: Mente, S.,Arnold, E.,Butler, T.,Chakrapani, S.,Chandrasekaran, R.,Cherry, K.,Dirico, K.,Doran, A.,Fisher, K.,Galatsis, P.,Green, M.,Hayward, M.,Humphrey, J.,Knafels, J.,Li, J.,Liu, S.,Marconi, M.,McDonald, S.,Ohren, J.,Paradis, V.,Sneed, B.,Walton, K.,Wager, T.; Ligand-protein interactions of selective casein kinase 1 delta inhibitors.; J.Med.Chem., 56:6819-6828, 2013; PubMed: 23919824; DOI: 10.1021/jm4006324

Experimental method

X-RAY DIFFRACTION (1.95 Å)