4KB8

CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANAMINE ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Casein kinase I isoform delta	polymer	331	38537.2	4	UniProt (P48730) Pfam (PF00069)	Homo sapiens (human)	CKI-delta, CKId, Tau-protein kinase CSNK1D
2	E, K (A, C)	1-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}-N-methylmethanamine	non-polymer		296.3	2	Chemie (1QN)
3	F, G, I, J, L... (A, B, C, D)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
4	H, N (B, D)	N-benzyl-4-(pyridin-3-yl)pyrimidin-2-amine	non-polymer		262.3	2	Chemie (1QO)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	254	Chemie (HOH)

Sequence modifications

A, B, C, D: 3 - 317 (UniProt: P48730)

PDB	External Database	Details
Met -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Leu -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Arg 0	-	expression tag
Gly 1	-	expression tag
Ser 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	154148.9
Non-Polymers*	Number of molecules	12
	Total formula weight	1885.8
All*	Total formula weight	156034.7

*Water molecules are not included.