4K9X
Complex of human CYP3A4 with a desoxyritonavir analog
Summary for 4K9X
| Entry DOI | 10.2210/pdb4k9x/pdb |
| Related | 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-methylbutanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate (3 entities in total) |
| Functional Keywords | cytochrome p450 3a4, alpha-beta protein, cytochrome p450 fold, monooxygenase, cytochrome p450 reductase, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
| Total number of polymer chains | 1 |
| Total formula weight | 56867.96 |
| Authors | Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2013-04-21, release date: 2013-06-19, Last modification date: 2023-09-20) |
| Primary citation | Sevrioukova, I.F.,Poulos, T.L. Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. Biochemistry, 52:4474-4481, 2013 Cited by PubMed: 23746300DOI: 10.1021/bi4005396 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
Download full validation report
