4K9X
Complex of human CYP3A4 with a desoxyritonavir analog
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytochrome P450 3A4 | polymer | 487 | 55757.8 | 1 | UniProt (P08684) Pfam (PF00067) In PDB | Homo sapiens (human) | 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxygenase, Taurochenodeoxycholate 6-alpha-hydroxylase |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-methylbutanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate | non-polymer | 493.7 | 1 | Chemie (8AW) |
Sequence modifications
A: 21 - 503 (UniProt: P08684)
PDB | External Database | Details |
---|---|---|
- | Leu 3 | deletion |
- | Ile 4 | deletion |
- | Pro 5 | deletion |
- | Asp 6 | deletion |
- | Leu 7 | deletion |
- | Ala 8 | deletion |
- | Met 9 | deletion |
- | Glu 10 | deletion |
- | Thr 11 | deletion |
- | Trp 12 | deletion |
- | Leu 13 | deletion |
- | Leu 14 | deletion |
- | Leu 15 | deletion |
- | Ala 16 | deletion |
- | Val 17 | deletion |
- | Ser 18 | deletion |
- | Leu 19 | deletion |
- | Val 20 | deletion |
- | Leu 21 | deletion |
- | Leu 22 | deletion |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 55757.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1110.1 | |
All* | Total formula weight | 56868.0 |