4K71
Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
Summary for 4K71
Entry DOI | 10.2210/pdb4k71/pdb |
Descriptor | Serum albumin, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (5 entities in total) |
Functional Keywords | mhc class i, lipid transport, endosome recycling, endosome |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P02768 P61769 Cell membrane; Single-pass type I membrane protein (By similarity): P55899 |
Total number of polymer chains | 6 |
Total formula weight | 219084.02 |
Authors | Schmidt, M.M.,Townson, S.A.,Andreucci, A.,Dombrowski, C.,Erbe, D.V.,King, B.,Kovalchin, J.T.,Masci, A.,Murillo, A.,Schirmer, E.B.,Furfine, E.S.,Barnes, T.M. (deposition date: 2013-04-16, release date: 2013-10-23, Last modification date: 2014-02-05) |
Primary citation | Schmidt, M.M.,Townson, S.A.,Andreucci, A.J.,King, B.M.,Schirmer, E.B.,Murillo, A.J.,Dombrowski, C.,Tisdale, A.W.,Lowden, P.A.,Masci, A.L.,Kovalchin, J.T.,Erbe, D.V.,Wittrup, K.D.,Furfine, E.S.,Barnes, T.M. Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface. Structure, 21:1966-1978, 2013 Cited by PubMed: 24120761DOI: 10.1016/j.str.2013.08.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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