4K71

Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor

4K71 の概要

• エントリーDOI: 10.2210/pdb4k71/pdb
• 分子名称: Serum albumin, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (5 entities in total)
• 機能のキーワード: mhc class i, lipid transport, endosome recycling, endosome
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P02768 P61769; Cell membrane; Single-pass type I membrane protein (By similarity): P55899
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 219084.02

構造登録者

Schmidt, M.M.,Townson, S.A.,Andreucci, A.,Dombrowski, C.,Erbe, D.V.,King, B.,Kovalchin, J.T.,Masci, A.,Murillo, A.,Schirmer, E.B.,Furfine, E.S.,Barnes, T.M. (登録日: 2013-04-16, 公開日: 2013-10-23, 最終更新日: 2014-02-05)

• 主引用文献: Schmidt, M.M.,Townson, S.A.,Andreucci, A.J.,King, B.M.,Schirmer, E.B.,Murillo, A.J.,Dombrowski, C.,Tisdale, A.W.,Lowden, P.A.,Masci, A.L.,Kovalchin, J.T.,Erbe, D.V.,Wittrup, K.D.,Furfine, E.S.,Barnes, T.M.; Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface.; Structure, 21:1966-1978, 2013; PubMed: 24120761; DOI: 10.1016/j.str.2013.08.022

実験手法

X-RAY DIFFRACTION (2.4 Å)