4K6Z

The Jak1 kinase domain in complex with compound 37

Summary for 4K6Z

Entry DOI	10.2210/pdb4k6z/pdb
Descriptor	Tyrosine-protein kinase JAK1, (1R,2S)-2-{[8-oxo-2-(1H-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein: P23458
Total number of polymer chains	1
Total formula weight	35067.93
Authors	Fong, R.,Lupardus, P.J. (deposition date: 2013-04-16, release date: 2013-10-02, Last modification date: 2013-10-23)
Primary citation	Labadie, S.,Barrett, K.,Blair, W.S.,Chang, C.,Deshmukh, G.,Eigenbrot, C.,Gibbons, P.,Johnson, A.,Kenny, J.R.,Kohli, P.B.,Liimatta, M.,Lupardus, P.J.,Shia, S.,Steffek, M.,Ubhayakar, S.,Abbema, A.V.,Zak, M. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorg.Med.Chem.Lett., 23:5923-5930, 2013 Cited by PubMed: 24042009 DOI: 10.1016/j.bmcl.2013.08.082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.73 Å)

Structure validation