4K6Z
The Jak1 kinase domain in complex with compound 37
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 1 | UniProt (P23458) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 1, JAK-1 |
| 2 | B (A) | (1R,2S)-2-{[8-oxo-2-(1H-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile | non-polymer | 321.3 | 1 | Chemie (1Q3) | |||
| 3 | C (A) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34746.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 321.3 | |
| All* | Total formula weight | 35067.9 |
