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4K5H

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine

Summary for 4K5H
Entry DOI10.2210/pdb4k5h/pdb
Related4K5D 4K5E 4K5F 4K5G 4K5I 4K5J 4K5K
DescriptorNitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywordsnitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceBos taurus (bovine)
Cellular locationCell membrane : P29473
Total number of polymer chains2
Total formula weight102318.09
Authors
Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2013-04-14, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citationJing, Q.,Li, H.,Chreifi, G.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23:5674-5679, 2013
Cited by
PubMed: 23993333
DOI: 10.1016/j.bmcl.2013.08.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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