Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HEM A 501 |
| Chain | Residue |
| A | TRP180 |
| A | TYR477 |
| A | H4B502 |
| A | 1Q6503 |
| A | HOH623 |
| A | HOH675 |
| A | HOH690 |
| A | ARG185 |
| A | CYS186 |
| A | SER228 |
| A | PHE355 |
| A | SER356 |
| A | TRP358 |
| A | GLU363 |
| A | TRP449 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE H4B A 502 |
| Chain | Residue |
| A | SER104 |
| A | VAL106 |
| A | ARG367 |
| A | ALA448 |
| A | TRP449 |
| A | HEM501 |
| A | GOL506 |
| A | HOH609 |
| A | HOH623 |
| A | HOH639 |
| A | HOH723 |
| B | TRP447 |
| B | PHE462 |
| B | HIS463 |
| B | GLN464 |
| B | GLU465 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1Q6 A 503 |
| Chain | Residue |
| A | GLN249 |
| A | VAL338 |
| A | PHE355 |
| A | TRP358 |
| A | TYR359 |
| A | GLU363 |
| A | TYR477 |
| A | HEM501 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 504 |
| Chain | Residue |
| A | GLY188 |
| A | TRP358 |
| A | VAL420 |
| A | SER428 |
| A | HOH670 |
| A | HOH695 |
| A | HOH721 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 505 |
| Chain | Residue |
| A | ARG252 |
| A | ASN368 |
| A | ARG374 |
| A | HOH753 |
| A | HOH767 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 506 |
| Chain | Residue |
| A | VAL106 |
| A | ARG367 |
| A | HIS373 |
| A | H4B502 |
| A | HOH609 |
| A | HOH631 |
| A | HOH767 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 507 |
| Chain | Residue |
| A | CYS96 |
| A | CYS101 |
| B | CYS96 |
| B | CYS101 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEM B 501 |
| Chain | Residue |
| B | TRP180 |
| B | ARG185 |
| B | CYS186 |
| B | SER228 |
| B | PHE355 |
| B | SER356 |
| B | TRP358 |
| B | GLU363 |
| B | TRP449 |
| B | TYR477 |
| B | H4B502 |
| B | 1Q6503 |
| B | HOH616 |
| B | HOH619 |
| B | HOH650 |
| B | HOH666 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE H4B B 502 |
| Chain | Residue |
| A | TRP447 |
| A | PHE462 |
| A | HIS463 |
| A | GLU465 |
| B | SER104 |
| B | ARG367 |
| B | ALA448 |
| B | TRP449 |
| B | HEM501 |
| B | GOL506 |
| B | HOH609 |
| B | HOH627 |
| B | HOH650 |
| B | HOH708 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1Q6 B 503 |
| Chain | Residue |
| B | ACT505 |
| B | HOH636 |
| B | HOH652 |
| B | GLN249 |
| B | VAL338 |
| B | ASN340 |
| B | TRP358 |
| B | TYR359 |
| B | GLU363 |
| B | HEM501 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 504 |
| Chain | Residue |
| B | TRP358 |
| B | VAL420 |
| B | SER428 |
| B | HOH672 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 505 |
| Chain | Residue |
| B | ARG252 |
| B | ASN368 |
| B | ARG374 |
| B | 1Q6503 |
| B | HOH625 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 506 |
| Chain | Residue |
| B | VAL106 |
| B | ARG367 |
| B | HIS373 |
| B | H4B502 |
| B | HOH609 |
| B | HOH649 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG185-TRP192 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P35228","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
