4K47
Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct
Summary for 4K47
Entry DOI | 10.2210/pdb4k47/pdb |
Related | 4K48 |
Descriptor | Leucine--tRNA ligase, [(1R,5R,6R,8S)-6-(6-aminopurin-9-yl)-3'-[(R)-oxidanyl(phenyl)methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1,3,5-triene]-8-yl]methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total) |
Functional Keywords | leucyl-trna synthetase, benzoxaboroles, antibacterial, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Streptococcus pneumoniae |
Cellular location | Cytoplasm (By similarity): B8ZKS5 |
Total number of polymer chains | 1 |
Total formula weight | 22043.98 |
Authors | Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. (deposition date: 2013-04-12, release date: 2013-09-04, Last modification date: 2024-03-20) |
Primary citation | Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Sci Rep, 3:2475-2475, 2013 Cited by PubMed: 23959225DOI: 10.1038/srep02475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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