4K47
Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine--tRNA ligase | polymer | 192 | 21091.5 | 1 | UniProt (B8ZKS5) Pfam (PF13603) | Streptococcus pneumoniae | Leucyl-tRNA synthetase, LeuRS |
| 2 | B (A) | [(1R,5R,6R,8S)-6-(6-aminopurin-9-yl)-3'-[(R)-oxidanyl(phenyl)methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1,3,5-triene]-8-yl]methyl dihydrogen phosphate | non-polymer | 568.3 | 1 | Chemie (WMP) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 228 - 410 (UniProt: B8ZKS5)
| PDB | External Database | Details |
|---|---|---|
| Met 227 | - | expression tag |
| Ser 399 | Cys 399 | engineered mutation |
| Leu 411 | - | expression tag |
| Glu 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21091.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 952.5 | |
| All* | Total formula weight | 22044.0 |
