4K43
Crystal structure of actin in complex with synthetic AplC tail analogue GC04 [N-{(1E,4R,5R,7E,9S,10S,11S)-4,10-dimethoxy-11-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-5,9-dimethyl-6-oxododeca-1,7-dien-1-yl}-N-methylformamide]
Summary for 4K43
Entry DOI | 10.2210/pdb4k43/pdb |
Related | 1QZ5 4K41 4K42 |
Descriptor | Actin, alpha skeletal muscle, CALCIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | cell motility, gelsolin, contractile protein |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Cytoplasm, cytoskeleton: P68135 |
Total number of polymer chains | 2 |
Total formula weight | 85723.15 |
Authors | Pereira, J.H.,Petchprayoon, C.,Moriarty, N.W.,Fink, S.J.,Cecere, G.,Paterson, I.,Adams, P.D.,Marriott, G. (deposition date: 2013-04-11, release date: 2014-10-01, Last modification date: 2024-02-28) |
Primary citation | Pereira, J.H.,Petchprayoon, C.,Hoepker, A.C.,Moriarty, N.W.,Fink, S.J.,Cecere, G.,Paterson, I.,Adams, P.D.,Marriott, G. Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues. Chemmedchem, 9:2286-2293, 2014 Cited by PubMed: 25047814DOI: 10.1002/cmdc.201402150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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