4JZF

Structure of factor VIIA in complex with the inhibitor 2-{2-[(3-carbamoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid

Summary for 4JZF

• Entry DOI: 10.2210/pdb4jzf/pdb
• Related: 4JZD 4JZE
• Descriptor: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), 2-{2-[(3-carbamoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid, ... (7 entities in total)
• Functional Keywords: glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35369.25

Authors

Wei, A.,Anumula, R. (deposition date: 2013-04-02, release date: 2013-08-21, Last modification date: 2023-09-20)

• Primary citation: Bolton, S.A.,Sutton, J.C.,Anumula, R.,Bisacchi, G.S.,Jacobson, B.,Slusarchyk, W.A.,Treuner, U.D.,Wu, S.C.,Zhao, G.,Pi, Z.,Sheriff, S.,Smirk, R.A.,Bisaha, S.,Cheney, D.L.,Wei, A.,Schumacher, W.A.,Hartl, K.S.,Liu, E.,Zahler, R.,Seiler, S.M.; Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.; Bioorg.Med.Chem.Lett., 23:5239-5243, 2013; PubMed: 23927973; DOI: 10.1016/j.bmcl.2013.06.028

Experimental method

X-RAY DIFFRACTION (1.84 Å)