4JZD
Structure of factor VIIA in complex with the inhibitor 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
Summary for 4JZD
Entry DOI | 10.2210/pdb4jzd/pdb |
Related | 4JZE 4JZF |
Descriptor | Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid, ... (7 entities in total) |
Functional Keywords | glycoprotein, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35909.78 |
Authors | Jacobson, B.L.,Anumula, R. (deposition date: 2013-04-02, release date: 2013-08-21, Last modification date: 2023-09-20) |
Primary citation | Bolton, S.A.,Sutton, J.C.,Anumula, R.,Bisacchi, G.S.,Jacobson, B.,Slusarchyk, W.A.,Treuner, U.D.,Wu, S.C.,Zhao, G.,Pi, Z.,Sheriff, S.,Smirk, R.A.,Bisaha, S.,Cheney, D.L.,Wei, A.,Schumacher, W.A.,Hartl, K.S.,Liu, E.,Zahler, R.,Seiler, S.M. Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold. Bioorg.Med.Chem.Lett., 23:5239-5243, 2013 Cited by PubMed: 23927973DOI: 10.1016/j.bmcl.2013.06.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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