4JZD

Structure of factor VIIA in complex with the inhibitor 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1NJ H 301

Chain	Residue
H	HIS57
H	GLY219
H	GLY226
H	1NJ302
H	SO4306
H	GOL309
H	HOH583
H	HOH594
H	HOH595
H	ASP189
H	SER190
H	LYS192
H	GLY193
H	SER195
H	SER214
H	TRP215
H	GLY216

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1NJ H 302

Chain	Residue
H	PRO246
H	ARG247
H	PRO248
H	1NJ301
H	SO4304
H	SO4306
H	HOH527
H	HOH579
H	HOH602
H	HOH645
H	HOH650
L	SER119
L	LEU120
L	LEU121
L	THR128
L	PRO129
L	THR130
L	GLU132
L	HOH335

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA H 303

Chain	Residue
H	ARG84
H	HIS109

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 H 304

Chain	Residue
H	GLN143
H	ARG147
H	LYS192
H	ARG247
H	1NJ302
H	SO4306
H	HOH503
H	HOH533
H	HOH561
H	HOH595
H	HOH602

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 305

Chain	Residue
H	MET164
H	THR165
H	ARG230
H	HOH570

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 306

Chain	Residue
H	LYS192
H	1NJ301
H	1NJ302
H	SO4304
H	HOH479
H	HOH563
H	HOH598

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 307

Chain	Residue
H	THR98
H	THR99
H	PRO170
H	HOH520
H	HOH548

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 308

Chain	Residue
H	GLN81
H	SER82
H	ARG83
H	HOH562

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 309

Chain	Residue
H	LEU41
H	HIS57
H	1NJ301
H	HOH590
H	HOH598
H	HOH626

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 201

Chain	Residue
H	ARG129
L	CYS91
L	CYS102
L	ASP104

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	239
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---