4JU6
Crystal structure of hcv ns5b polymerase in complex with compound 24
Summary for 4JU6
Entry DOI | 10.2210/pdb4ju6/pdb |
Related | 3MWV 4JTY 4JTZ 4JU1 4JU2 4JU3 4JU4 4JU6 4JU7 4JVQ 4JY0 4JY1 |
Descriptor | Genome polyprotein, 2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}-5-phenoxybenzoic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | rna-directed rna polymerase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Hepatitis C virus (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
Total number of polymer chains | 2 |
Total formula weight | 129015.38 |
Authors | Coulombe, R. (deposition date: 2013-03-24, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Stammers, T.A.,Coulombe, R.,Duplessis, M.,Fazal, G.,Gagnon, A.,Garneau, M.,Goulet, S.,Jakalian, A.,Laplante, S.,Rancourt, J.,Thavonekham, B.,Wernic, D.,Kukolj, G.,Beaulieu, P.L. Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay. Bioorg.Med.Chem.Lett., 23:6879-6885, 2013 Cited by PubMed: 24176401DOI: 10.1016/j.bmcl.2013.09.102 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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