3MWV

Crystal structure of HCV NS5B polymerase

Summary for 3MWV

• Entry DOI: 10.2210/pdb3mwv/pdb
• Related: 3MWW
• Descriptor: Genome polyprotein (2 entities in total)
• Functional Keywords: hcv virus rdrp ns5b polymerase, transferase
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 2
• Total formula weight: 128571.27

Authors

Coulombe, R. (deposition date: 2010-05-06, release date: 2010-10-27, Last modification date: 2023-09-06)

• Primary citation: LaPlante, S.R.,Gillard, J.R.,Jakalian, A.,Aubry, N.,Coulombe, R.,Brochu, C.,Tsantrizos, Y.S.,Poirier, M.,Kukolj, G.,Beaulieu, P.L.; Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.; J.Am.Chem.Soc., 132:15204-15212, 2010; PubMed: 20942454; DOI: 10.1021/ja101358s

Experimental method

X-RAY DIFFRACTION (2.2 Å)