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4JSH

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-((3-(piperidin-4-ylmethoxy)phenoxy)methyl)pyridin-2-amine

Summary for 4JSH
Entry DOI10.2210/pdb4jsh/pdb
Related4JSE 4JSF 4JSG 4JSI 4JSJ 4JSK 4JSL 4JSM
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (rat)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100178.86
Authors
Li, H.,Poulos, T.L. (deposition date: 2013-03-22, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citationJing, Q.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21:5323-5331, 2013
Cited by
PubMed: 23867386
DOI: 10.1016/j.bmc.2013.06.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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