4JSM
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-(((5-(((3-fluorophenethyl)amino)methyl)pyridin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
Summary for 4JSM
Entry DOI | 10.2210/pdb4jsm/pdb |
Related | 4JSE 4JSF 4JSG 4JSH 4JSI 4JSJ 4JSK 4JSL |
Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Cell membrane : P29473 |
Total number of polymer chains | 2 |
Total formula weight | 102270.04 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2013-03-22, release date: 2013-08-07, Last modification date: 2023-09-20) |
Primary citation | Jing, Q.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorg.Med.Chem., 21:5323-5331, 2013 Cited by PubMed: 23867386DOI: 10.1016/j.bmc.2013.06.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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