4JQH

Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain

Summary for 4JQH

Entry DOI	10.2210/pdb4jqh/pdb
Related	3L6J 4IAE 4IAH 4IAM
Descriptor	Alr2278 protein, 4-{[(4-carboxybutyl)(2-{2-[(4'-phenoxybiphenyl-4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid, MALONIC ACID, ... (4 entities in total)
Functional Keywords	guanylyl cyclase, analogue of bay58-2667, signaling protein
Biological source	Nostoc sp.
Total number of polymer chains	2
Total formula weight	43830.76
Authors	Kumar, V.,van den Akker, F. (deposition date: 2013-03-20, release date: 2013-11-20, Last modification date: 2024-02-28)
Primary citation	von Wantoch Rekowski, M.,Kumar, V.,Zhou, Z.,Moschner, J.,Marazioti, A.,Bantzi, M.,Spyroulias, G.A.,van den Akker, F.,Giannis, A.,Papapetropoulos, A. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. J.Med.Chem., 56:8948-8952, 2013 Cited by PubMed: 24090476 DOI: 10.1021/jm400539d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation