4JQ7

Crystal structure of EGFR kinase domain in complex with compound 2a

Summary for 4JQ7

• Entry DOI: 10.2210/pdb4jq7/pdb
• Descriptor: Epidermal growth factor receptor, (2S)-2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-2-phenylethanol (3 entities in total)
• Functional Keywords: transferase, tyrosine kinase domain, atp-binding domain, autophosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 37808.71

Authors

Peng, Y.H.,Wu, J.S. (deposition date: 2013-03-20, release date: 2013-06-19, Last modification date: 2023-11-08)

• Primary citation: Peng, Y.H.,Shiao, H.Y.,Tu, C.H.,Liu, P.M.,Hsu, J.T.,Amancha, P.K.,Wu, J.S.,Coumar, M.S.,Chen, C.H.,Wang, S.Y.,Lin, W.H.,Sun, H.Y.,Chao, Y.S.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y.; Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors; J.Med.Chem., 56:3889-3903, 2013; PubMed: 23611691; DOI: 10.1021/jm400072p

Experimental method

X-RAY DIFFRACTION (2.73 Å)