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4JQ7

Crystal structure of EGFR kinase domain in complex with compound 2a

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Epidermal growth factor receptorpolymer32837401.31UniProt (P00533)
Pfam (PF07714)
Homo sapiens (human)Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2B
(A)
(2S)-2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-2-phenylethanolnon-polymer407.51Chemie (KJQ)
3C
(A)
waterwater18.025Chemie (HOH)
Sequence modifications
A: 672 - 997 (UniProt: P00533)
PDBExternal DatabaseDetails
Gly 670-expression tag
Pro 671-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37401.3
Non-Polymers*Number of molecules1
Total formula weight407.5
All*Total formula weight37808.7
*Water molecules are not included.

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PDB entries from 2024-12-18

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