4JQ0

Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin

Summary for 4JQ0

• Entry DOI: 10.2210/pdb4jq0/pdb
• Related: 4JPZ
• Descriptor: Fibroblast growth factor 12, Calmodulin, Sodium channel protein type 5 subunit alpha, ... (4 entities in total)
• Functional Keywords: ef hand, ion channel, membrane, transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane ; Multi-pass membrane protein : P61328; Nucleus : P62158; Cytoplasm, cytoskeleton, spindle : Q14524
• Total number of polymer chains: 3
• Total formula weight: 66287.82

Authors

Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S. (deposition date: 2013-03-19, release date: 2014-05-21, Last modification date: 2024-02-28)

• Primary citation: Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S.; Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.; Nat Commun, 5:4896-4896, 2014; PubMed: 25232683; DOI: 10.1038/ncomms5896

Experimental method

X-RAY DIFFRACTION (3.84 Å)