4JQ0

Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor 12	polymer	243	27444.3	1	UniProt (P61328) Pfam (PF00167) In PDB	Homo sapiens (human)	FGF-12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor
2	C	Calmodulin	polymer	149	16852.5	1	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) In PDB	Homo sapiens (human)	CaM
3	D	Sodium channel protein type 5 subunit alpha	polymer	191	21830.6	1	UniProt (Q14524) In PDB	Homo sapiens (human)	HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5
4	C	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

D: 1773 - 1940 (UniProt: Q14524)

PDB	External Database	Details
Met 1750	-	expression tag
Gly 1751	-	expression tag
Ser 1752	-	expression tag
Ser 1753	-	expression tag
His 1754	-	expression tag
His 1755	-	expression tag
His 1756	-	expression tag
His 1757	-	expression tag
His 1758	-	expression tag
His 1759	-	expression tag
Ser 1760	-	expression tag
Ser 1761	-	expression tag
Gly 1762	-	expression tag
Leu 1763	-	expression tag
Val 1764	-	expression tag
Pro 1765	-	expression tag
Arg 1766	-	expression tag
Gly 1767	-	expression tag
Ser 1768	-	expression tag
His 1769	-	expression tag
Met 1770	-	expression tag
Ala 1771	-	expression tag
Ser 1772	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	66127.5
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	66287.8

*Water molecules are not included.