4JPK

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab

Summary for 4JPK

• Entry DOI: 10.2210/pdb4jpk/pdb
• Related: 4JPI 4JPJ
• Descriptor: Putative VRC01 germline precursor Fab heavy chain, Putative VRC01 germline precursor Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ... (5 entities in total)
• Functional Keywords: hiv-1 gp120, cd4 binding, vrc01-like broadly neutralizing antibodies, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 68596.35

Authors

Julien, J.-P.,Jardine, J.,Schief, W.R.,Wilson, I.A. (deposition date: 2013-03-19, release date: 2013-04-10, Last modification date: 2023-09-20)

• Primary citation: Jardine, J.,Julien, J.P.,Menis, S.,Ota, T.,Kalyuzhniy, O.,McGuire, A.,Sok, D.,Huang, P.S.,MacPherson, S.,Jones, M.,Nieusma, T.,Mathison, J.,Baker, D.,Ward, A.B.,Burton, D.R.,Stamatatos, L.,Nemazee, D.,Wilson, I.A.,Schief, W.R.; Rational HIV immunogen design to target specific germline B cell receptors.; Science, 340:711-716, 2013; PubMed: 23539181; DOI: 10.1126/science.1234150

Experimental method

X-RAY DIFFRACTION (2.4 Å)