4JP4

Mmp13 in complex with a reverse hydroxamate Zn-binder

Summary for 4JP4

Entry DOI	10.2210/pdb4jp4/pdb
Related	4JPA
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	matrix metalloprotease, calcium binding, zinc binding, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P45452
Total number of polymer chains	2
Total formula weight	40534.29
Authors	Gerhardt, S.,Hargreaves, D. (deposition date: 2013-03-19, release date: 2014-03-05, Last modification date: 2024-03-20)
Primary citation	De Savi, C.,Waterson, D.,Pape, A.,Lamont, S.,Hadley, E.,Mills, M.,Page, K.M.,Bowyer, J.,Maciewicz, R.A. Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg.Med.Chem.Lett., 23:4705-4712, 2013 Cited by PubMed: 23810497 DOI: 10.1016/j.bmcl.2013.05.089 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation