4JNC

Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor

Summary for 4JNC

Entry DOI	10.2210/pdb4jnc/pdb
Descriptor	Bifunctional epoxide hydrolase 2, 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide (3 entities in total)
Functional Keywords	epoxide hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P34913
Total number of polymer chains	1
Total formula weight	36543.83
Authors	Shewchuk, L.M. (deposition date: 2013-03-15, release date: 2013-06-05, Last modification date: 2023-09-20)
Primary citation	Thalji, R.K.,McAtee, J.J.,Belyanskaya, S.,Brandt, M.,Brown, G.D.,Costell, M.H.,Ding, Y.,Dodson, J.W.,Eisennagel, S.H.,Fries, R.E.,Gross, J.W.,Harpel, M.R.,Holt, D.A.,Israel, D.I.,Jolivette, L.J.,Krosky, D.,Li, H.,Lu, Q.,Mandichak, T.,Roethke, T.,Schnackenberg, C.G.,Schwartz, B.,Shewchuk, L.M.,Xie, W.,Behm, D.J.,Douglas, S.A.,Shaw, A.L.,Marino, J.P. Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorg.Med.Chem.Lett., 23:3584-3588, 2013 Cited by PubMed: 23664879 DOI: 10.1016/j.bmcl.2013.04.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation